Past Events

Fifth DAPSOC Symposium, 2009: Clinical Proteomics: From Bedside to Bench

DAPSOC turns five years old! The 5th DAPSOC Symposium ‘Clinical Proteomics: From Bedside to Bench’ was held at the University of Southern Denmark at Odense on Dec. 1, 2009. For the second year in a row we had an overwhelming attendance. A total of 150 delegates, speakers and exhibitors were present and it turned out to be the largest DAPSOC Symposium to date. Fourteen (14) companies exhibited their products and services. As usual, the Symposium was held at the conference section of the University of Southern Denmark that provided an excellent environment for lectures, poster sessions and exhibitions.

After a short introduction by DAPSOC president Ole N. Jensen (Univ. Southern Denmark), the Symposium was kicked off with a plenary lecture by Thomas P. Conrads (Univ. Pittsburgh Medical Center, USA) who described novel sample preparation and quantitative proteomics technologies for the analysis of clinical samples, such as fixed tissue sections and tissue interstitial fluids.  The following speaker, Keiryn Bennett (CeMM, Vienna, Austria) described how multidimensional separations and mass spectrometry are combined in proteomics approaches to study diseases of the eye. Lennart Martens (Univ. Ghent, Belgium) completed the morning session by presentation the computational and bioinformatics aspects of proteomics, including analysis of MS database entries and how to design the best experiments for targeted analysis of proteins in complex samples.

The after-lunch session was dedicated to the young scientists and included four short talks by phd-students and postdocs from Danish Universities: Stine Lønnerup Christensen (AU), Hye Ryung Jung (SDU) and Gitte Lund Christensen (KU/Glostrup Hospital) and Adelina Rogowska-Wreszinska (SDU). The topics varied from agricultural proteomics using LC-MS/MS (SRM), to cell signalling and epigenetics studies by SILAC and MS/MS, and to 2DE and mass spectrometry studies of mitochondrial function. This session gave a very nice overview of the many different strategies that are available to proteomics researchers and the quality of the presentations bodes well for the future of these young scientists and for proteomics in Denmark.

The last session was kicked off by Martin R. Larsen (SDU) who provided an overview of his phospho- and glycoproteomics studies of brain samples, including tissues and cerebrospinal fluids. Martin L. Miller (Memorial Sloan Kettering Center, N.Y., USA) finished this session and the symposium by describing efforts to use systematic measurements by quantitative proteomics data to develop and test models for cell signalling networks and drug perturbations. The potential of this approach for systems biology studies of cell signalling is still in its infancy but in a few years this may be the way to develop and test new drug candidates and their mode-of-action.

The following companies were exhibiting their products during the Symposium:  Advion, Agilent Technologies, AH Diagnostics, AME Bioscience, Applied Biosystems, Bruker Daltonics Scandinavia, Dionex Denmark A/S, Fermentas Life Sciences, In-Vitro, Life Tech, Proxeon A/S,  Sigma-Aldrich Danmark, ThermoFisher Scientific and Waters A/S.

During coffee breaks and the lunch break there was ample time for discussions among the participants, speakers and exhibitors.

A reception and dinner event was included and attended by approximately 45 delegates and the invited speakers. There was a lively discussion of the events of the day, socializing and ‘networking’ over a very good meal.

The DAPSOC committee thanks the participants and the exhibitors for their support of the annual symposium, and also Vivian Juhl, Helle M. Mortensen and Søren Andersen for their assistance during planning and execution of yet another successful Symposium.

Mark your calendar: The 6th DAPSOC is planned for December 7, 2010, at the University of Southern Denmark, Odense, DK.


Fourth DAPSOC Symposium, 2008: Quantitative Proteomics

The 4th DAPSOC Symposium 'Quantitative Proteomics' was held at the University of Southern Denmark at Odense on Dec. 2, 2008. This symposium saw an overwhelming attendance of 150 delegates, speakers and exhibitors, and turned out to be the largest DAPSOC Symposium to date. A total of 15 companies exhibited their products and services. The Symposium was held at the conference section of the University of Southern Denmark that provided an excellent environment for lectures, poster sessions and exhibitions.

After a short introduction by DAPSOC president Ole N. Jensen (Univ. Southern Denmark), the Symposium was kicked off with a plenary lecture by Robert Beynon (Univ. Liverpool, UK) who described novel quantitative proteomics technologies and their applications in various biological systems.  The following speaker, Claus Jørgensen (Toronto, Canada) demonstrated how a SILAC based quantitative proteomics approach can reveal convergent signalling events in eukaryotes. Jörn Dengjel (SDU, DK) completed the morning session by giving an introduction to autophagocytosis and how proteomics can address important questions in this branch of cell biology.

The after-lunch session was dedicated to the young scientists and included three short talks by phd-students and postdocs: Justyna Czarna-Bahl (SSI/SDU), Arkadiusz Nawrocki (SDU) and Maria Rentsch (DTU Aqua). The topics varied from immunological proteomics using LC-MS, to agricultural and nutrigenomics applications of 2DE and mass spectrometry.

The last session was kicked off by Jesper V. Olsen (MPI Biochemistry, München) who demonstrated how quantitative phosphoproteomics can be integrated in cell biology studies to advance our understanding of cell signalling events. Per Hägglund (DTU) described studies of redox processes using ICAT technology to monitor Cys-containing proteins. Tine E. Thingholm (OUH/SDU) finished this session by giving an overview of iTRAQ based strategies for proteomics and phosphoproteomics in the context of insulin signalling.

The following companies were exhibiting their products during the Symposium:  Advion, Agilent Technologies, Applied Biosystems, Biochemfusion, Bruker Daltonics Scandinavia, Dandiag A/S, Denator AB, Dionex Denmark A/S, GE Healthcare Life Sciences, LI-COR Biosciences, Proxeon A/S, Qiagen Nordic, Sigma-Aldrich Danmark, ThermoFisher Scientific and Waters A/S.

During coffee breaks and the lunch break there was ample time for discussions among the participants, speakers and exhibitors.

For the first time, a dinner event was included and attended by approximately 60 delegates and the invited speakers. This was a very good opportunity to discuss the events of the day and ‘do some networking’ over a very good meal. This will be a reoccurring event at the 2009 Symposium.

The DAPSOC committee thanks the participants and the exhibitors for their support of the annual symposium, and also Vivian Juhl, Helle M. Mortensen and Søren Andersen for their assistance during planning and execution of this successful Symposium.


Third DAPSOC Symposium: Systems Biology and Proteomics

The 3rd DAPSOC Symposium 'Systems Biology and Proteomics' was held at the University of Southern Denmark at Odense on Dec. 4, 2007. This symposium turned out to be the largest DAPSOC Symposium to date, with more than 120 delegates and an exhibition with 14 companies. The Symposium was held in the recently added conference section of the University of Southern Denmark that provided an excellent environment for lectures, poster sessions and exhibitions.

After a short introduction by DAPSOC president Ole N. Jensen (Univ. Southern Denmark), the Symposium was kicked off with a plenary lecture by Ruedi Aebersold (ETH Zürich, CH) who described several targeted mass spectrometry approaches to bring proteomics to the systems biology level. The following speaker, Kristian Helin (BRIC, Copenhagen University, DK) emphasized the need for a reductionistic view to study the molecular implications of protein methylation and demethylation in epigenetics and cancer research. Connie Jimenez (Free University, Amsterdam, NL) then introduced her work in oncoproteomics and the utility and reproducibility of sample prefractionation of tumor tissue prior to proteomic analysis by mass spectrometry and bioinformatics.

The next session emphasized proteomics in agricultural sciences. Klaas Jan Van Wijk (Cornell Univ., New York) described his recent work on proteomics of plant organelles in maize using various protein and peptide separation techniques and several different ways to quantify proteins by mass spectrometry. Emøke Bendixen (Aarhus University, DK) presented how proteomics workflows are used in pig breeding research, including nice examples of gut proteomics and integrative approaches to understand animal physiology.

The last session was kicked off by Kasper Lage (Technical University of Denmark) who demonstrated how computational techniques and data mining methods can be integrated to derive biological function and predict disease genes from biological and bibliographical databases. Kamilla Pedersen (Aarhus University, DK) led the audience through a 'mystery case' to identify D. melanogaster genes involved in pathogenesis, including both genomics and proteomics technologies. The last speaker, Kåre Lehmann (Aalborg University, DK) gave an overview of large-scale techniques for gene expression analysis, including efficient and economic SAGE methods adapted for the new 454 and Solexa high-throughput sequencers.

During coffee breaks and the lunch break there was ample time for discussions among the participants, speakers and exhibitors. The following companies were exhibiting their products:  Advion, Bruker Daltonics Scandinavia, Denator AB, Dionex Denmark A/S, GE Healthcare Life Sciences, Holm & Halby, Krüger Aquacare A/S, Nonlinear Dynamics, Olympus Danmark A/S, Proxeon A/S, Qiagen Nordic, Roche Diagnostics A/S, Sigma-Aldrich Danmark, ThermoFisher Scientific. The DAPSOC committee thanks the exhibitors for their support of the annual symposium.


Second DAPSOC Symposium: Analysis of protein complexes: Purification, interaction, dynamics

The Second DAPSOC Symposium entitled 'Analysis of protein complexes: Purification, interaction, dynamics' was held on December 5, 2006 at the University of Southern Denmark.

Ole N. Jensen welcomed the speakers and attendees and gave a short introduction of the activities of DAPSOC, EuPA and HUPO. Speakers included Carol V. Robinson (Cambridge, UK) who described her outstanding work on protein complexes and subunit architecture using electrospray ionization mass spectrometry. , Thomas Jørgensen (Univ. Southern Denmark) described how to use hydrogen/deuterium exchange and mass spectrometry to study protein stability, folding and interactions and the attempts to circumvent ‘scrambling’ of deuterons during MS/MS. Hans Peter Braun (Univ. Hannover, D) gave a very nice overview of the use of blue native gel electrophoresis to study plant organelles and protein complexes and Niels Heegaard (Statens Serum Institute) described a new approach for biomarker discovery that is targeting circulating microparticles in blood.  Henning Urlaub (MPI Biophysics, Göttingen, D) described recent work on structure/function studies of protein-RNA complexes using UV cross-linking and mass spectrometry. Jens S. Andersen (SDU) presented a talk on organellar proteomics using both quantitative mass spectrometry and fluorescence microscopy to study the dynamics of large protein complexes in the nucleus. Finally, Bernhard Küster (Cellzome, D) introduced the 'Kinobeads' based approach for affinity-based enrichment of human protein kinases and described how this method can be used in drug discovery to identify drug targets using proteomics technologies.

The auditorium was completely full (>90 persons) attesting to the interest in the topics covered by the speakers. A total of ten companies presented their products and tools for proteomics. This year, DAPSOC provided sandwiches and drinks for free during a combined lunch/exhibition/poster session that was a great success. Many participants provided positive feedback and suggestions.


The First DAPSOC Symposium: Phosphoproteomics and Cell Signaling

The First DAPSOC Symposium entitlede 'Phosphoproteomics and Cell Signaling' was held on Dec. 8, 2005, at the University of Southern Denmark.  More than 70 attendees from industry, academia and national laboratories were gathered for a full day symposium that featured international and Danish speakers. Dr. Albert Sickmann (Würzburg, D) presented novel proteomic strategies for the analysis of platelet membrane proteins and Dr. Jeroen Krijgsveld (Utrecht, NL) described mass spectrometry approaches for  quantitative proteomic analysis of the fruit fly and embryonic stem cells. In a fascinating closing lecture, Dr. Lars Juhl Jensen (EMBL, D) outlined current bioinformatics approaches to investigate protein interaction networks. Additional speakers were Drs. Blagoy Blagoev, Albrecht Gruhler, Thomas Kledal, Tia Sorsa, Majbrit Hjerrild and Martin R. Larsen. The excellent scientific presentations and the lively discussions among the delegates made this symposium a very successful kick-off event for DAPSOC. The support from more than 10 vendors was greatly appreciated.

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